The liver converts a small amount of vinyl chloride into an even more powerful toxin that stays in the body and causes health problems like angiosarcoma an aggressive type of liver cancer that starts inside blood vessels.
Vinyl chloride exposure liver.
The evidence of a causal link between vinyl chloride exposure and liver cancer is anyhow confirmed.
Shipped as a liquefied compressed gas.
Meta analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality.
There is inadequate ascertainment of unequivocal diagnoses.
Angiosarcoma and hepatocellular carcinoma.
In 2007 the international agency for research on cancer established the association of vcm with hepatocellular carcinoma hcc though only on the basis of the few cases available.
Occupational safety health administration provides information about exposure limits to vinyl chloride.
Breathing vinyl chloride for long periods of time can result in permanent liver damage immune reactions nerve damage and liver cancer.
In the very first study about the dangers of vinyl chloride published by patty in 1930 it was disclosed that exposure of test animals to just a single short term high dose of vinyl chloride caused liver damage.
Cases of liver angiosarcoma have been reported among individuals employed in pvc fabrication facilities and an epidemiological study has demonstrated a significant association between exposure to pvc dust and the risk of lung cancer mortality.
The evidence for a carcinogenic risk has been extended to jobs associated with poly vinyl chloride exposure.
Chloroethene chloroethylene ethylene monochloride monochloroethene monochloroethylene vc vcm vinyl chloride monomer vcm colorless gas or liquid below 7 f with a pleasant odor at high concentrations.
Bofetta p matisane l mundt ka dell ld.
It also has other toxic effects on the liver and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma.
In 1949 a russian publication discussed the finding that vinyl chloride caused liver injury among workers.
Liver damage is the most serious health risk of vinyl chloride.
Liver side effects of vinyl chloride.
However the data on which this conclusion is based is incomplete.
How can exposures be reduced.
This substance has been found in at least 616 of the 1 662 national priority list sites identified by the environmental protection agency epa.
The causal link between vinyl chloride exposure and lung cancer must be further investigated.
Vinyl chloride is also known to cause fibrosis scarring of the liver which is a risk factor for hepatocellular carcinoma.
Iarc monographs on the evaluation of carcinogenic risks to humans vol 97.
Vinyl chloride monomer is a known cause of angiosarcoma of the liver.
